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Association Between Placebo-Activated Neural Systems and Antidepressant Responses: Neurochemistry of Placebo Effects in Major Depression


JAMA Psychiatry


Abstract

Importance
High placebo responses have been observed across a wide range of pathologies, severely impacting drug development.

Objective
To examine neurochemical mechanisms underlying the formation of placebo effects in patients with major depressive disorder (MDD).

Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: A PBR28 PET Brain Imaging Study


The American Journal of Psychiatry


Abstract

Objective:
The purpose of this study was to determine whether microglial activity, measured using translocator-protein positron emission tomography (PET) imaging, is increased in unmedicated persons presenting with subclinical symptoms indicating that they are at ultra high risk of psychosis and to determine whether microglial activity is elevated in schizophrenia after controlling for a translocator-specific genetic polymorphism.

Long-term Risk of Dementia in Persons With Schizophrenia


JAMA Psychiatry


Abstract

Importance
Although schizophrenia is associated with several age-related disorders and considerable cognitive impairment, it remains unclear whether the risk of dementia is higher among persons with schizophrenia compared with those without schizophrenia.

Suicide and Chronic Traumatic Encephalopathy


The Journal of Neuropsychiatry


Abstract

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